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Formation and Mechanism Long-term UV exposure triggers melanin production to prevent sun damage Oxidative stress due to heat damages skin cells Appearance Face, hands, arms, neck, and feet Distinguishing Features Uneven tanning of the body (Appears only on the exposed areas Freckles or sun spots Often appears with aging Uneven Skin Tone In uneven skin tone, there are no defined dark spots, but general skin dullness or patchy pigmentation
Diagnosis is made by exclusion of alcohol abuse and other causes of liver disease (HBV-related hepatitis, HCV-related hepatitis, autoimmune liver diseases, polycystic ovary syndrome, drug-induced liver disease and congenital causes such as hereditary hemochromatosis, Wilsons disease, alpha-1 antitrypsin deficit)
This makes it a safer option for sensitive skin types and for use during post-procedure recovery